In the fast-paced and morbidly kitschy game Hit Z Road, you and your fellow players embark on a road trip going south from Chicago along America's famous Route 66 — now infested by zombies. As you travel though a deck of adventure cards rife with dangers, you battle zombie hordes, drive abandoned school buses, scavenge for gas and bullets, and explore a darkened, tainted American countryside full of shambling undead, haunted carnivals, and plumes of toxic gas. Your goal is to stay alive until you reach the safe, sandy beaches of the California coast.

Three different stages of adventure cards create an experience of increasing difficulty and ensure that each playthrough is unique. Each round begins with an auction that determines both player order and which cards you will encounter. Since the resources used for bidding are the same as those used to battle the oncoming zombie hordes, your survival depends as much on your resource management as it does upon winning those bidding wars. The player who either accumulates the most points or survives the longest wins.

Zombies of all types await, with cannibals, anti-personnel mines and radioactive wastes also being among the hazards awaiting the players. Who will survive the zombie onslaught?